THERAPY-RELATED ACUTE MYELOID-LEUKEMIA WITH T(8-21) IN A CHILD WITH PREVIOUS EWINGS-SARCOMA

Cases of secondary acute myeloid leukemia (AML) occurring after treatm ent for an Ewing's sarcoma are uncommon. Therapy-related AML with t(8; 21) translocation is an entity which has been well characterized. A ca se of AML-2 with t(8;21) and t(3;15) occurring 4 years after treatment for an Ewing's sarcoma with cyclophosphamide doxorubicin, vincristine , dactinomycin, and radiotherapy, is reported. Autologous bone marrow transplantation was performed during second remission, 23 months after diagnosis. Reverse transcriptase polymerase chain reaction of the AML 1/ETO fusion gene product was performed in order to monitor the qualit y of the remission. The patient currently remains in remission 24 mont hs after the hone marrow transplantation. (C) 1997 Wiley-Liss, Inc.