Retinol and retinol-binding protein in neonates with bronchopulmonary dysplasia

Citation
R. Valdes-ramos et al., Retinol and retinol-binding protein in neonates with bronchopulmonary dysplasia, NUTR RES, 19(10), 1999, pp. 1551-1557
Citations number
15
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
NUTRITION RESEARCH
ISSN journal
02715317 → ACNP
Volume
19
Issue
10
Year of publication
1999
Pages
1551 - 1557
Database
ISI
SICI code
0271-5317(199910)19:10<1551:RARPIN>2.0.ZU;2-4
Abstract
The incidence of Bronchopulmonary Dysplasia (BPD) is high in preterm very-l ow-birth-weight infants, and prematurity is one the main causes of neonatal and infant morbidity and mortality in Mexico. The objective of the study w as to evaluate vitamin A status of infants at risk for BPD. Serum retinol a nd Retinol-Binding-Protein concentrations were measured, after obtaining pa rents informed consent, 17 infants with birthweights <1500g, who needed Mec hanical Mandatory Ventilation for at least 3 days after birth were included all of whom developed BPD. Anthropometric measurements (length, weight, he ad and arm circumferences) and blood samples (1 mt) were obtained at birth, 4,7,14, 21 and 28 days of life. Data are presented as means +/- standard d eviation and quartiles, and were analyzed by One-Way ANOVA. Mean retinol co ncentrations were significantly lower by day 28 than at birth, while REP re mained constant, thus decreasing the Retinol/RBP molar ratio, indicating vi tamin A deficiency in these infants. It is necessary to evaluate the effect of Vitamin A supplementation in these infants in order to explore its effe ct on the incidence of the disease. (C) 1999 Elsevier Science Inc.