Peripheral neuropathy in healthy men volunteers anesthetized with 1.25 MACsevoflurane for 8 hours

Two men volunteers developed peripheral neuropathy after prolonged anesthes ia with 1.25 minimum alveolar concentration sevoflurane at an inflow rate o f 2 L/minute of fresh gas that caused concurrent administration of relative ly large doses (ppm-hrs) of the degradation product of sevoflurane, compoun d A. Other similarly treated volunteers had lesser degrees of transient neu ropathy. This result does not prove but raises the question of whether comp ound A or other factors associated with sevoflurane anesthesia can predispo se patients to peripheral neuropathy.