The behavior of 6-methyl-2-thiouracil towards Wittig-Horner reagents

Authors
Yakout, ESMA Giurgius, DB Boulos, LS
Citation
Esma. Yakout et al., The behavior of 6-methyl-2-thiouracil towards Wittig-Horner reagents, PHOSPHOR SU, 148, 1999, pp. 177-187
Citations number
24
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
ISSN journal
10426507 → ACNP
Volume
148
Year of publication
1999
Pages
177 - 187
Database
ISI
SICI code
1042-6507(1999)148:<177:TBO6TW>2.0.ZU;2-2
Abstract
6-Methyl-2-thiouracil (1) reacts with Wittig-Horner (2a-e) reagents to give the new products 3, 4, 6, 7 and 9 along with the alkylated derivatives 5, 8 and 10. When 1 was treated with 2e and/or 2f, the alkylated compound 10 i s the sole reaction prduct. Possible reaction mechanism are considered and the structural assignments are based on compatible analytical and spectrosc opic results.