METHYLATION RING-OPENING OF 3,3-DISUBSTITUTED 2,3-EPOXY ALCOHOLS - SYNTHESIS OF CHIRAL QUATERNARY FRAGMENTS FOR ASSEMBLY OF BRIARAN DITERPENES

Authors
BALASUBRAMANIAM RP MOSS DK WYATT JK SPENCE JD GEE A NANTZ MH
Citation
Rp. Balasubramaniam et al., METHYLATION RING-OPENING OF 3,3-DISUBSTITUTED 2,3-EPOXY ALCOHOLS - SYNTHESIS OF CHIRAL QUATERNARY FRAGMENTS FOR ASSEMBLY OF BRIARAN DITERPENES, Tetrahedron, 53(22), 1997, pp. 7429-7444
Citations number
49
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
53
Issue
22
Year of publication
1997
Pages
7429 - 7444
Database
ISI
SICI code
0040-4020(1997)53:22<7429:MRO32A>2.0.ZU;2-8
Abstract
Two chiral quaternary carbon-containing fragments suitable for elabora tion to the briaran diterpenes were obtained by regioselective methyla tion of functionalized 3,3-disubstituted 2,3-epoxy-1-ols. The factors which favor methylation at the more hindered position of a trisubstitu ted 2.3-epoxy alcohol were determined. (C) 1997 Elsevier Science Ltd.