Predicting protein structure using only sequence information

Authors
Karplus, K Barrett, C Cline, M Diekhans, M Grate, L Hughey, R
Citation
K. Karplus et al., Predicting protein structure using only sequence information, PROTEINS, 1999, pp. 121-125
Citations number
20
Categorie Soggetti
Biochemistry & Biophysics
Journal title
PROTEINS-STRUCTURE FUNCTION AND GENETICS
ISSN journal
08873585 → ACNP
Year of publication
1999
Supplement
3
Pages
121 - 125
Database
ISI
SICI code
0887-3585(1999):<121:PPSUOS>2.0.ZU;2-A
Abstract
This paper presents results of blind predictions submitted to the GASPS pro tein structure prediction experiment. We made predictions using the SAM-T98 method, an iterative hidden Markov model-based method for constructing pro tein family profiles. The method is purely sequence-based, using no structu ral information, and yet was able to predict structures as well, as all but five of the structure-based methods in GASPS. (C) 1999 Wiley Liss, Inc.