Childhood and adolescent bipolar disorder has been less studied than adult-
onset bipolar illness. Case reports of mania in childhood can be found as e
arly as the mid nineteenth century, however. Historically, several factors
have made the accurate diagnosis of bipolar disorder in children difficult:
(1) clinical bias against the diagnosis of mania in children, (2) low base
rate of disorder, (3) symptom overlap between bipolar disorder and other m
ore prevalent childhood-onset psychiatric disorders, and (4) developmental
constraints and variability in clinical presentation.