Finding the needle in the haystack. The dereplication of natural product extracts

Authors
Cordell, GA Shin, YG
Citation
Ga. Cordell et Yg. Shin, Finding the needle in the haystack. The dereplication of natural product extracts, PUR A CHEM, 71(6), 1999, pp. 1089-1094
Citations number
10
Categorie Soggetti
Chemistry
Journal title
PURE AND APPLIED CHEMISTRY
ISSN journal
00334545 → ACNP
Volume
71
Issue
6
Year of publication
1999
Pages
1089 - 1094
Database
ISI
SICI code
0033-4545(199906)71:6<1089:FTNITH>2.0.ZU;2-6
Abstract
Dereplication is an integral part of the early stages of the drug discovery process, where there is a focus on the rapid identification of novel, biol ogically active metabolites from natural sources. We describe a strategy an d a system for dereplication and offer several examples of its successful a ppplication.