Chemistry of ginkgolides: structure-activity relationship as PAF antagonists

Authors
Hu, LH Chen, ZL Cheng, XF Xie, YY
Citation
Lh. Hu et al., Chemistry of ginkgolides: structure-activity relationship as PAF antagonists, PUR A CHEM, 71(6), 1999, pp. 1153-1156
Citations number
13
Categorie Soggetti
Chemistry
Journal title
PURE AND APPLIED CHEMISTRY
ISSN journal
00334545 → ACNP
Volume
71
Issue
6
Year of publication
1999
Pages
1153 - 1156
Database
ISI
SICI code
0033-4545(199906)71:6<1153:COGSRA>2.0.ZU;2-1
Abstract
The ginkgolides represent a challenge for the organic chemist owing to thei r unique cage structure and their high potential biological activity. They were found to be potential PAF antagonists. The results of studies carried out in our laboratory are discussed, leading to conclusions on ginkgolides quantitative structure-activity relationship by using CoMFA and the probabl e pharmacophore and the interaction fashion between ginkgolides and PAF rec eptor.