Results are presented from an experiment to estimate the contribution of pl
asma on ray paths through the protonosphere to measurements of total electr
on content (TEC) using Global Positioning System (GPS) signals. Simulations
using the Sheffield University plasmasphere ionosphere model show that obs
ervations of GPS satellites made at two stations separated by a few degrees
of latitude could involve a common ionospheric volume but very different i
ntersection geometries of the ray paths with protonospheric flux tubes. Exp
erimental results demonstrate that, on average, higher equivalent Vertical
TECs are measured on ray paths to the south than those to the north of the
European midlatitude stations considered here. The observations are discuss
ed in terms of the known asymmetries of the protonospheric flux tubes: and
caution is advised in the use of thin-shell ionospheric models for precise
determination of TEC or correction for its effects on GPS systems.