Comprehensive MR imaging protocol for stroke management: Tissue sodium concentration as a measure of tissue viability in nonhuman primate studies andin clinical studies

PURPOSE: To investigate sodium magnetic resonance (MR) imaging for monitori ng tissue viability in stroke. MATERIALS AND METHODS: A comprehensive MR imaging protocol used to measure apparent diffusion coefficient and perfusion parameters was extended to inc lude sodium imaging. Tissue sodium concentration was estimated by using a t wo-compartment model. This protocol lasted less than 45 minutes. These para meters were followed over the first 6 hours in a nonhuman primate model (n = 2) of acute embolic stroke without or with thrombolytic therapy. This pro tocol was used in patients in whom acute (<24 hours, n = 11) or nonacute (g reater than or equal to 24 hours, n = 31) stroke was ultimately confirmed. RESULTS: The animal model showed abnormal diffusion and perfusion parameter s in the lesion immediately after embolization, and these remained abnormal for over 6 hours. Tissue sodium concentration increased with time (5.7 mmo l/L/h) unless halted with thrombolytic therapy. Regions with sodium concent rations over 70 mmol/L were histochemically verified as being infarcted. In patients in whom stroke older than 6 hours was clinically confirmed, sodiu m concentrations over 70 mmol/L were found in the appropriate brain regions . CONCLUSION: Tissue sodium concentration provides a sensitive measure of tis sue viability that is complementary to the diagnostic role of diffusion and perfusion imaging for ischemic insult.