INHIBITION OF 5-AMINOLEVULINIC ACID (ALA) DEHYDRATASE BY UNDISSOCIATED LEVULINIC ACID DURING ALA EXTRACELLULAR FORMATION BY RHODOBACTER-SPHAEROIDES

Authors
SASAKI K WATANABE M NISHIO N
Citation
K. Sasaki et al., INHIBITION OF 5-AMINOLEVULINIC ACID (ALA) DEHYDRATASE BY UNDISSOCIATED LEVULINIC ACID DURING ALA EXTRACELLULAR FORMATION BY RHODOBACTER-SPHAEROIDES, Biotechnology letters, 19(5), 1997, pp. 421-424
Citations number
13
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Biotechnology letters → ACNP
ISSN journal
01415492
Volume
19
Issue
5
Year of publication
1997
Pages
421 - 424
Database
ISI
SICI code
0141-5492(1997)19:5<421:IO5A(D>2.0.ZU;2-H
Abstract
The inhibition of ALA dehydratase by levulinic acid during ALA extrace llular formation of Rhodobacter sphaeroides correlated with the concen tration of undissociated form of levulinic acid irrespective of cultur e pH. The inhibition constant, Ki, of intracellular ALA dehydratase by Dixon plots was 2.95 mu M. Undissociated levulinic acid therefore fun ctions as an inhibitor of ALA dehydratase.