The influence of structure and lipophilicity of hydantoin derivatives on anticonvulsant activity

The lipophilicity of a representative number of hydantoin derivatives was e xperimentally determined by RP-HPLC. The stationary phase of RP-HPLC proved a good model to simulate effects of membrane transport. These experimental values were correlated to theoretically estimated lipophilicity values on the basis of global minima structures of the compounds studied. Both these lipophilicity and structure similarities within a proposed pharmacological model for binding the hydantoin derivatives along the sodium channel were c lassified with respect to their biological activity.