Experimental design methodologies to optimize monobutyltin chloride determination by hydride generation gas phase molecular absorption spectrometry

A hydride generation gas phase molecular absorption spectrometry (HG-GPMAS) method for the determination of butyltin compound is optimized by experime ntal design. This method is based on the conversion of the butyltin chlorid e into gaseous monobutyltin hydride by adding a sodium tetrahydroborate (II I) solution. The hydride generated is collected in a liquid nitrogen cryoge nic trap. This is revolatilized, driven to the quartz how cell and measured with GPMAS with diode array detection. A Plackett-Burmann design is used f or the study of the factors that influence the absorption signal. The optim ization of the parameters affecting the production and collection of the mo nobutyltin hydride is achieved using a central composite design. Partial le ast square (PLS), multiple linear regression (MLR) and univariate calibrati on are applied to the spectra obtained. The quality parameters (detection l imits and precision) for the butyltin chloride are reported. An interferenc e study is made. (C) 1999 Elsevier Science B.V. All rights reserved.