Novel conversion of thiols into disulfides, via S-nitrosothiol intermediates using trichloronitromethane

Authors
Demir, AS Igdir, AC Mahasneh, AS
Citation
As. Demir et al., Novel conversion of thiols into disulfides, via S-nitrosothiol intermediates using trichloronitromethane, TETRAHEDRON, 55(42), 1999, pp. 12399-12404
Citations number
27
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
55
Issue
42
Year of publication
1999
Pages
12399 - 12404
Database
ISI
SICI code
0040-4020(19991015)55:42<12399:NCOTID>2.0.ZU;2-E
Abstract
An efficient oxidative coupling of thiols to give disulfides via thionitrit e (S-nitrosothiol) intermediate is described using trichloronitromethane as an efficient reagent in organic solvents and water. Cysteine and glutathio ne are converted into the corresponding disulfides in water in high yields. (C) 1999 Elsevier Science Ltd. All rights reserved.