The EGF receptor as central transducer of heterologous signalling systems

The cross-talk between heterologous signalling systems of the cell represen ts a new dimension of complexity in the molecular communication network tha t governs a great variety of physiological processes. In pathophysiological ly transformed cells, key elements of this network could offer unique oppor tunities for pharmacological intervention. In this article, the current sta te of knowledge regarding the role of epidermal growth factor (EGF) in such a network is described and the recent advances made in the elucidation of the mechanism underlying EGF receptor transactivation are discussed.