Analysis of the H gene, the central untranslated region and the proximal coding part of the F gene of wild-type and vaccine canine distemper viruses

Authors
Haas, L Liermann, H Harder, TC Barrett, T Lochelt, M von Messling, V Baumgartner, W Greiser-Wilke, I
Citation
L. Haas et al., Analysis of the H gene, the central untranslated region and the proximal coding part of the F gene of wild-type and vaccine canine distemper viruses, VET MICROB, 69(1-2), 1999, pp. 15-18
Citations number
7
Categorie Soggetti
Veterinary Medicine/Animal Health",Microbiology
Journal title
VETERINARY MICROBIOLOGY
ISSN journal
03781135 → ACNP
Volume
69
Issue
1-2
Year of publication
1999
Pages
15 - 18
Database
ISI
SICI code
0378-1135(19990901)69:1-2<15:AOTHGT>2.0.ZU;2-7
Abstract
This paper summarizes the results of the genetic analysis of several parts of the genome of canine distemper virus (CDV) field isolates and vaccine vi ruses. The haemagglutinin (H) gene analysis showed that recent viruses did not differ significantly from vaccine strains. The analysis of the long unt ranslated region between the matrix (M) and fusion (F) gene revealed distin ct genetic heterogeneity. The putative F protein start codon AUG(461) Of va ccine strain Onderstepoort was found to be mutated in all wild-type isolate s and in another vaccine strain. The proximal coding part of the F gene was well conserved. Phylogenetic analysis of this segment showed the presence of several cocirculating CDV genotypes. (C) 1999 Elsevier Science B.V. All rights reserved.