HA-1-92, A new antifungal antibiotic produced by Streptomyces CDRIL-312: Fermentation, isolation, purification and biological activity

Authors
Harindran, J Gupte, TE Naik, SR
Citation
J. Harindran et al., HA-1-92, A new antifungal antibiotic produced by Streptomyces CDRIL-312: Fermentation, isolation, purification and biological activity, WORLD J MIC, 15(4), 1999, pp. 425-430
Citations number
21
Categorie Soggetti
Biotecnology & Applied Microbiology
Journal title
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
ISSN journal
09593993 → ACNP
Volume
15
Issue
4
Year of publication
1999
Pages
425 - 430
Database
ISI
SICI code
0959-3993(199908)15:4<425:HANAAP>2.0.ZU;2-S
Abstract
A new antifungal antibiotic, HA-1-92, was isolated from the biomass of Stre ptomyces CDRIL-312, by extracting in butanol and further purified by silica gel column chromatography followed by preparative TLC. The antibiotic is p resumed to be an oxohexaene macrolide and showed promising antifungal activ ity against yeasts and filamentous fungi including human and plant pathogen s. It was found to be less toxic in mice than known oxohexaenes.