The traditional view conceptualizes pain as being directly associated with
the extent of physical pathology. The observations that there are a number
of patients who report pain in the absence of physical pathology, the conve
rse, asymptomatic individuals who evidence objective physical pathology, th
e inconsistency in response of patients with identical diagnoses, and the l
ow association between impairments and disability suggest that factors othe
r than physical pathology contribute to the reports of pain. The role of be
havioral, cognitive, and affective factors have each been shown to have dir
ect effects on the report of pain, adaptation, and response to treatment, a
s well as indirect effects by influencing sympathetic nervous system and ne
urochemical factors associated with nociception. The direct and indirect ef
fects of behavioral (operant), cognitive, and affective factors in chronic
pain are described.