The absolute configuration of an intermediate cyclic sulfoximine in the asymmetric synthesis of transition-state analog inhibitors of gamma-glutamylcysteine synthetase

The crystal structure of a cyclic sulfoximine, 2-amino-4-(4-ethyl-1,3-dioxo -4,5-dihydra-1,2-thiazol-1-yl)butanoic acid, C9H16N2O4S, was determined to ascertain its stereochemistry. The absolute configuration of the chiral S a tom was S on the basis of the (S)-alpha-carbon derived from the synthetic p recursor, L-homocysteine.