This article, based on a collaborative research project on genetic knowledg
e production, examines the relations between on- and off-line field sites r
elated to rh, ee heritable diseases: epidermolysis bullosa, chondrodysplasi
a, and Marfan syndrome. Field sites include the Web sites, listservs, and c
hat rooms run by lay health advocacy groups and biomedical professionals as
well laboratories, clinics, and support groups meetings. The analysis uses
the notion of location work, and the concept of the node that links differ
ent elements in a network, in describing a relational approach to multisite
d ethnography. The article presents three case studies that examine shiftin
g locations between online and face-to-face relations, hyperlinks as a meta
phor for interactive knowledge production, and the process of negotiating a
networked ethics.