C. Prakash et Re. Clouse, Cyclic vomiting syndrome in adults: Clinical features and response to tricyclic antidepressants, AM J GASTRO, 94(10), 1999, pp. 2855-2860
OBJECTIVE: Cyclic vomiting syndrome (CVS) has been described infrequently i
n adults, and treatment in both children and adults remains unsatisfactory.
We report clinical features of a group of adults with CVS and anecdotal ou
tcome from open-label treatment with tricyclic antidepressants, medications
that have some efficacy in other unexplained gastrointestinal disorders.
METHODS: Clinical data were examined from 17 adult patients with CVS seen o
ver a IO-yr period, each having been treated with a tricyclic antidepressan
t. Outpatient records were reviewed, clinical outcome was extracted using a
priori criteria, and findings were compared with 37 patients having usual
functional nausea and vomiting who also received tricyclic antidepressant t
herapy.
RESULTS: Symptoms in CVS began at age 35 yr (range 14-73 yr); the average e
pisode length was 6 days (range 1-21 days) and the symptom-free interval av
eraged 3.1 months (range 0.5-6 months). Vomiting cycles typically began wit
hout warning, and fewer than one-third of the subjects reported a prodrome
or potential trigger event, such as menstrual periods, pregnancy, or large
meals. Sleep was seemingly beneficial in 23.5%. Tricyclic antidepressant th
erapy was associated with complete remission in 17.6% and partial response
in 58.8%, but was less effective than for functional nausea and vomiting (p
= 0.02).
CONCLUSIONS: CVS is a rare diagnosis with distinctive features in adults. D
uration of episodes and cycles varies considerably across subjects. In open
-label, uncontrolled use, tricyclic antidepressants appear beneficial for s
ome subjects but are less effective in CVS than in chronic, persistent func
tional nausea and vomiting. (C) 1999 by Am. Cell. of Gastroenterology.