Alpha(1)-acid glycoprotein, age, and sex in mood disorders

Authors
Young, RC Patel, A Meyers, BS Kakuma, T Alexopoulos, GS
Citation
Rc. Young et al., Alpha(1)-acid glycoprotein, age, and sex in mood disorders, AM J GER PS, 7(4), 1999, pp. 331-334
Citations number
19
Categorie Soggetti
Psychiatry
Journal title
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
ISSN journal
10647481 → ACNP
Volume
7
Issue
4
Year of publication
1999
Pages
331 - 334
Database
ISI
SICI code
1064-7481(199923)7:4<331:AGAASI>2.0.ZU;2-A
Abstract
Serum alpha(1)-acid glycoprotein (AAG) reportedly can increase with age in the normal population especially among women. In 33 patients with unipolar major depression or bipolar disorder serum AAG was measured by age. The aut hors noted a positive association with age, particularly in depressed femal e patients (n = 18; r(s) = 0.61; P < 0.01). The authors discuss implication s for drug pharmacokinetics. Investigation of AAG in mood disorders needs t o take age and sex into consideration.