Prognostic value of electrophysiological markers in Alzheimer's disease

The authors assessed the usefulness of event-related potentials (ERP) and f lash visual evoked potentials (FVEP) as prognostic markers in a sample of 2 5 subjects with probable Alzheimer's disease. (AD). ERP and FVEP recordings were obtained from 21 and 23 subjects, respectively. Ranking of the annual rate of change in cognitive scales vs. baseline ERP/FVEP latencies was com pared and those with longer FVEP N-2 component latencies showed slower subs equent rates of decline (tau = 0.32; z = 2.16; P = 0.015), suggesting that further study of FVEP responses as prognostic markers in AD is warranted.