Quantitative MR diffusion mapping and cyclosporine-induced neurotoxicity

Apparent diffusion coefficient maps of two patients with cyclosporine-induc ed neurotoxicity showed areas of increased diffusion that corresponded to t he characteristic regions of signal change on routine T2-weighted sequences . The majority of lesions subsequently resolved without residual T2 or diff usion signal alteration. These findings suggest that, in our patients, the neurotoxic effects of cyclosporine resulted in a partially reversible extra vasation of fluid into the cerebral interstitium and were not associated wi th acute ischemia.