L-ALPHA-AMINOADIPATE REDUCES GLUTAMATE RELEASE FROM BRAIN-TISSUE EXPOSED TO COMBINED OXYGEN AND GLUCOSE DEPRIVATION

Authors
HAUGSTAD TS LANGMOEN IA
Citation
Ts. Haugstad et Ia. Langmoen, L-ALPHA-AMINOADIPATE REDUCES GLUTAMATE RELEASE FROM BRAIN-TISSUE EXPOSED TO COMBINED OXYGEN AND GLUCOSE DEPRIVATION, Journal of cerebral blood flow and metabolism, 17(5), 1997, pp. 567-570
Citations number
37
Categorie Soggetti
Neurosciences,"Endocrynology & Metabolism",Hematology
Journal title
Journal of cerebral blood flow and metabolism → ACNP
ISSN journal
0271678X
Volume
17
Issue
5
Year of publication
1997
Pages
567 - 570
Database
ISI
SICI code
0271-678X(1997)17:5<567:LRGRFB>2.0.ZU;2-O
Abstract
The effect of the glutamate analogue L-alpha-aminoadipate (alpha AA) o n the release of glutamate and gamma-aminobutyric acid (GABA) from rat hippocampal slices was investigated in vitro. Oxygen/glucose deprivat ion caused a large release of glutamate and GABA. alpha AA added durin g energy deprivation reduced the glutamate release in a dose-dependent manner (56% reduction at 5 mM), whereas GABA release was unchanged. W e speculate that ischemic glutamate release from the brain is mediated by a low affinity transport mechanism that is blocked by alpha AA.