Injection drug users frequently present to emergency departments with fever
. A careful history and physical examination with attention to anatomic loc
alization of symptoms and signs are often necessary to unmask unusual under
lying medical conditions. We report a case of a woman with recent injection
drug use who presented with fever, a palpable neck mass, and Pancoast's sy
ndrome. She had been seen recently at the ED of another hospital and discha
rged with oral antibiotics for presumed cellulitis. A mycotic aneurysm of t
he subclavian artery causing Pancoast's syndrome was later diagnosed by usi
ng computed tomography and angiography. A high index of suspicion for anato
mically localized infective processes should always be maintained with febr
ile injection drug users.