Expression of NPYY1 and CGRP1 receptors in human nasal mucosa: Implications in allergic rhinitis

Authors
Uddman, R Cantera, L Cardell, LO Edvinsson, L
Citation
R. Uddman et al., Expression of NPYY1 and CGRP1 receptors in human nasal mucosa: Implications in allergic rhinitis, ANN OTOL RH, 108(10), 1999, pp. 969-973
Citations number
34
Categorie Soggetti
Otolaryngology,"da verificare
Journal title
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
ISSN journal
00034894 → ACNP
Volume
108
Issue
10
Year of publication
1999
Pages
969 - 973
Database
ISI
SICI code
0003-4894(199910)108:10<969:EONACR>2.0.ZU;2-A
Abstract
Numerous nerve fibers containing neuropeptide Y (NPY) and calcitonin gene-r elated peptide (CGRP) have been found in the human nasal mucosa by means of immunocytochemistry. We detected NPY Y1 and CGRP1 receptors at the same lo cation using reverse transcriptase-polymerase chain reaction. The possibili ty of local release in connection with specific target receptors suggests a role for endogenous NPY and CGRP in the regulation of vascular tone, gland ular secretion, and epithelial functions.