Association of alterations in ParC and GyrA proteins with resistance of clinical isolates of Enterococcus faecium to nine different fluoroquinolones

Authors
Brisse, S Fluit, AC Wagner, U Heisig, P Milatovic, D Verhoef, J Scheuring, S Kohrer, K Schmitz, FJ
Citation
S. Brisse et al., Association of alterations in ParC and GyrA proteins with resistance of clinical isolates of Enterococcus faecium to nine different fluoroquinolones, ANTIM AG CH, 43(10), 1999, pp. 2513-2516
Citations number
31
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
43
Issue
10
Year of publication
1999
Pages
2513 - 2516
Database
ISI
SICI code
0066-4804(199910)43:10<2513:AOAIPA>2.0.ZU;2-C
Abstract
The parC and gyrA genes of 73 ciprofloxacin-resistant and 6 ciprofloxacin-s usceptible Enterococcus faecium clinical isolates were partly sequenced. Al terations in ParC and GyrA, possibly in combination with other resistance m echanisms, severely restricted the in vitro activities of the nine quinolon es tested. For all isolates, clinafloxacin and sitafloxacin showed the best activities.