Pharmacokinetics of isepamicin during continuous venovenous hemodiafiltration

The objective of this study was to analyze the pharmacokinetics of isepamic in during continuous venovenous hemodiafiltration. Six patients received 15 mg of isepamicin per kg of body weight. The mean isepamicin concentration peak in serum was 62.88 +/- 18.20 mg/liter 0.5 h after the infusion. The el imination half-life was 7.91 +/- 0.83 h, The mean total body clearance was 1.75 +/- 0.28 liters/h, and dialysate outlet (DO) clearance was 2.76 +/- 0. 59 liters/h. The mean volume of distribution was 19.83 +/- 2.95 liters. The elimination half-life, DO clearance, and volume of distribution were almos t constant. In this group of patients, the initial dosage of 15 mg/kg appea red to be adequate, but the dosage interval should be determined by monitor ing residual isepamicin concentrations in plasma.