Neurotropic and antitumor activities of silyl- and germyl-isoxazolin-2-yl derivatives

Authors
Lukevics, E Arsenyan, P Germane, S Shestakova, I
Citation
E. Lukevics et al., Neurotropic and antitumor activities of silyl- and germyl-isoxazolin-2-yl derivatives, APPL ORGAN, 13(10), 1999, pp. 795-798
Citations number
11
Categorie Soggetti
Chemistry
Journal title
APPLIED ORGANOMETALLIC CHEMISTRY
ISSN journal
02682605 → ACNP
Volume
13
Issue
10
Year of publication
1999
Pages
795 - 798
Database
ISI
SICI code
0268-2605(199910)13:10<795:NAAAOS>2.0.ZU;2-V
Abstract
Neurotropic and antitumor activities of the pyridyl-substituted 5-Si(Ge)-is oxazolines and (3-alkyl-4-triphenylgermylisoxazolin-2-yl)-5-carboxylic acid ethyl esters have been investigated. It has been shown that silylisoxazoli n-2-yl derivatives are more potent in protection against hypoxia and Corazo le convulsions than their analogues. Germylisoxazolin-2-yl compounds are st ronger tumor growth inhibitors and NO-inducers than their silyl analogues. Copyright (C) 1999 John Wiley & Sons, Ltd.