Synthesis and antiprotozoan properties of new 3,5-disubstituted-tetrahydro-2H-1,3,5-thiadiazine-2-thione derivatives

Authors
Ochoa, C Perez, E Perez, R Suarez, M Ochoa, E Rodriguez, H Barrio, AG Muelas, S Nogal, JJ Martinez, RA
Citation
C. Ochoa et al., Synthesis and antiprotozoan properties of new 3,5-disubstituted-tetrahydro-2H-1,3,5-thiadiazine-2-thione derivatives, ARZNEI-FOR, 49(9), 1999, pp. 764-769
Citations number
10
Categorie Soggetti
Pharmacology & Toxicology
Journal title
ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
ISSN journal
00044172 → ACNP
Volume
49
Issue
9
Year of publication
1999
Pages
764 - 769
Database
ISI
SICI code
0004-4172(199909)49:9<764:SAAPON>2.0.ZU;2-1
Abstract
In a search for antiprotozoan compounds, 34 new 3,5-disubstituted-tetrahydr o-2H-1,3,5-thiadiazine-2-thione derivatives were synthesized and tested in vitro against Trypanosoma cruzi and Trichomonas vaginalis. Some of them sho wed important antiprotozoan activity. In vivo assays of compounds which sho wed remarkable in vitro activity against T. vaginalis were carried out.