Cross-sectional imaging techniques are increasingly being considered as alt
ernative imaging modalities for colorectal screening. While CT-colonography
uses air to insufflate the colon, an enema containing small amounts of par
amagnetic contrast represents the basis for MR-colonography. Both technique
s provide large three-dimensional data sets of the abdomen, containing the
entire colon. Using sophisticated post-processing, the colon can be assesse
d in any desirable plane from various viewpoints. Thus even virtual endosco
pic views can be rendered to assess the inside of the colon. This chapter b
riefly describes the technical aspects underlying both CT- and MR-colonogra
phy. Advantages and disadvantages of the two techniques are critically disc
ussed, comparing them with one another as well as with conventional colonos
copy and barium enema.