Bleeding is one of the main challenges for endoscopists. Despite a large nu
mber of methods for haemostasis, several types of haemorrhage lack an adequ
ate therapeutic remedy. Argon plasma-coagulation (APC), a new method for th
e non-contact application of high-frequency current, promises to solve many
of these problems. Among 1164 patients treated in 2349 sessions using APC,
the indication was bleeding (due to tumour, intervention, angiodysplasia o
r coagulation disorders) in 305 patients (26%). The primary success rate wa
s over 99%, the rebleeding rate 1.6% and the complication rate less than 1%
, with zero mortality. Physical principles, indications, application parame
ters and results are discussed, especially in comparison with the Nd:YAG la
ser. APC is a new, efficacious, safe and easy-to-use method for the devital
ization of tissue and haemostasis, especially in problematic cases.