Molecule imprinting polymers (MIPs) with high chiral selectivity for N-alph
a-protected amino acids were synthesized in polar solvent using acrylamide
(AM) or combined functional monomer methacrylic acid (MAA) + vinyl pyridine
(VP). Factors that influence the chiral selectivity of MIPs and mechanisms
of the chiral recognition process were investigated. It was found that the
rigid structure and the polar functional group of the print molecule were
very important for the chiral selectivity of MIPs. For MIPs made using a co
mbined functional monomer, ionic and hydrophobic interaction may be respons
ible for the chiral recognition process in aqeous media. The number of bind
ing sites on MIPs and dissociation constants for the complex of enantiomers
and MIPs were determined by frontal chromatography analysis. Copyright (C)
1999 John Wiley & Sons, Ltd.