Determination of glycyrrhizin in Radix glycyrrhizae and its preparations by capillary zone electrophoresis

A capillary zone electrophoresis method was set up for the separation and d etermination of glycyrrhizin in Chinese medicinal preparations. Concentrati ons of Na2B4O7 were optimized, which showed that glycyrrhizin in the sample could be separated from interference in the running buffer of 30 mmol/L Na 2B4O7 Using declofenac as internal standard, the simple method was Linear i n the range 25-300 mu g/mL of glycyrrhizin, and good reproducibility was ob tained. The extracts of Radix glycyrrhizae and its preparations could be in jected directly for analysis without any pretreatment. Copyright (C) 1999 J ohn Wiley & Sons, Ltd.