The synthesis of a new class of oxytocin antagonists

Authors
Wisniewski, K Trojnar, J Riviere, P Haigh, R Yea, C Ashworth, D Melin, P Nilsson, A
Citation
K. Wisniewski et al., The synthesis of a new class of oxytocin antagonists, BIOORG MED, 9(19), 1999, pp. 2801-2804
Citations number
15
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
19
Year of publication
1999
Pages
2801 - 2804
Database
ISI
SICI code
0960-894X(19991004)9:19<2801:TSOANC>2.0.ZU;2-B
Abstract
The synthesis of a new class of oxytocin antagonists, with significantly mo dified C-terminal part, is described. The chemistry of the Mitsunobu reacti on was applied to obtain the key derivatives. In spite of the extensive mod ifications of previously described compound F792, the peptides retain biolo gical activity as oxytocin antagonists. (C) 1999 Elsevier Science Ltd. All rights reserved.