Generation of an UGI library of phosphate mimic-containing compounds and identification of novel dual specific phosphatase inhibitors

Authors
Bergnes, G Gilliam, CL Boisclair, MD Blanchard, JL Blake, KV Epstein, DM Pal, K
Citation
G. Bergnes et al., Generation of an UGI library of phosphate mimic-containing compounds and identification of novel dual specific phosphatase inhibitors, BIOORG MED, 9(19), 1999, pp. 2849-2854
Citations number
22
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
19
Year of publication
1999
Pages
2849 - 2854
Database
ISI
SICI code
0960-894X(19991004)9:19<2849:GOAULO>2.0.ZU;2-A
Abstract
The four-component Ugi reaction was utilized to prepare a library of dipept idic compounds in order to explore the binding requirements of the key cell cycle phosphatase, Cdc25. Several phosphate surrogates were incorporated i nto the Ugi product to mimic either the mono- or bis-phospholylated substra te. (C) 1999 Elsevier Science Ltd. All rights reserved.