Authors
Citation
Rl. Jarvest et al., Interaction of tyrosyl aryl dipeptides with S-aureus tyrosyl tRNA synthetase: Inhibition and crystal structure of a complex, BIOORG MED, 9(19), 1999, pp. 2859-2862
Citations number
9
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X
→ ACNP
Volume
9
Issue
19
Year of publication
1999
Pages
2859 - 2862
Database
ISI
SICI code
0960-894X(19991004)9:19<2859:IOTADW>2.0.ZU;2-U
Abstract
Tyrosyl aryl dipeptide inhibitors of S. aureus tyrosyl tRNA synthetase have
been identified with IC50 values down to 0.5 mu M. A crystal structure of
the enzyme complexed to one of the inhibitors shows occupancy of the tyrosy
l binding pocket coupled with inhibitor interactions to key catalytic resid
ues, (C) 1999 Elsevier Science Ltd. All rights reserved.