2-chloro-3-substituted-1,4-naphthoquinone inactivators of human cytomegalovirus protease

Authors
Ertl, P Cooper, D Allen, G Slater, MJ
Citation
P. Ertl et al., 2-chloro-3-substituted-1,4-naphthoquinone inactivators of human cytomegalovirus protease, BIOORG MED, 9(19), 1999, pp. 2863-2866
Citations number
21
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
19
Year of publication
1999
Pages
2863 - 2866
Database
ISI
SICI code
0960-894X(19991004)9:19<2863:2IOHC>2.0.ZU;2-E
Abstract
A random screening approach has identified 2-chloro-3-substituted-1,4-napht hoquinones as potent inactivators of HCMV protease. Enzyme inactivation is due to modification of Cys202. Two of the most potent compounds maintain ac tivity against HCMV in a plaque reduction assay. (C) 1999 Elsevier Science Ltd. Ail rights reserved.