A novel method to highly versatile monomeric PNA building blocks by multi component reactions

Authors
Domling, A Chi, KZ Barrere, M
Citation
A. Domling et al., A novel method to highly versatile monomeric PNA building blocks by multi component reactions, BIOORG MED, 9(19), 1999, pp. 2871-2874
Citations number
12
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
19
Year of publication
1999
Pages
2871 - 2874
Database
ISI
SICI code
0960-894X(19991004)9:19<2871:ANMTHV>2.0.ZU;2-T
Abstract
A novel approach to monomeric PNA building blocks by a solution phase Ugi m ulti component reaction (MCR) is described. The reaction is easily performe d in 96 well plates. The products precipitate from the reaction solution an d are thus obtained in high yields and purity. Those products are not amena ble by another multi step synthesis in such a diversity. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.