Structure-activity relationship in two series of aminoalkyl substituted coumarin inhibitors of gyrase B

Authors
Laurin, P Ferroud, D Schio, L Klich, M Dupuis-Hamelin, C Mauvais, P Lassaigne, P Bonnefoy, A Musicki, B
Citation
P. Laurin et al., Structure-activity relationship in two series of aminoalkyl substituted coumarin inhibitors of gyrase B, BIOORG MED, 9(19), 1999, pp. 2875-2880
Citations number
33
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
19
Year of publication
1999
Pages
2875 - 2880
Database
ISI
SICI code
0960-894X(19991004)9:19<2875:SRITSO>2.0.ZU;2-9
Abstract
Two series of aminosubstituted coumarins were synthesised and evaluated in vitro as inhibitors of DNA gyrase and as potential antibacterials. Novel no vobiocin-like coumarins, 4-(dialkylamino)-methylcoumarins and 4-((2-alkylam ino)ethoxy)coumarins, were discovered as gyrase B inhibitors with promising antibacterial activity in vitro. (C) 1999 Elsevier Science Ltd. All rights reserved.