Citation
K. Wang et al., N-15 NMR and electronic properties of S-nitrosothiols, BIOORG MED, 9(19), 1999, pp. 2897-2902
Citations number
24
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X
→ ACNP
Volume
9
Issue
19
Year of publication
1999
Pages
2897 - 2902
Database
ISI
SICI code
0960-894X(19991004)9:19<2897:NNAEPO>2.0.ZU;2-0
Abstract
Investigation of the N-15 NMR of S-nitrosothiols showed that primary and te
rtiary RSNOs have distinct N-15 chemical shifts around 730 and 790 ppm, res
pectively. Using N-15 NMR technique, the equilibrium constant of NO transfe
r between SNAP and GSH was found to be 0.74. For primary RSNOs, linear rela
tionships exist among N-15 NMR chemical shifts, reduction potentials, and t
he pK(a)s of their parent thiols. (C) 1999 Elsevier Science Ltd. All rights
reserved.