Dendrimer construction and macromolecular property modification via combinatorial methods

The design and utility of a family of isocyanate functionalized branched mo nomers, as well as others, are described. Use of these monomers in logical combinations for the construction of branched architectures leads to the fo rmation of unique, asymmetric dendritic species possessing multiple functio nalities. Ramifications of this combinatorial-based, macromolecular constru ction technique are discussed with respect to functional group positioning and the potential to create dynamic heterogenous surfaces resembling a mole cular "Rubik's sphere." (C) 1999 John Wiley & Sons, Inc.