Translocation (10;11)(p13;p15) in an infant acute myeloid leukemia with MLL gene rearrangement

Authors
Marco, F Bureo, E Delgado, MD Richard, C Cuadrado, MA Retortillo, JAP Recio, M Zubizarreta, A
Citation
F. Marco et al., Translocation (10;11)(p13;p15) in an infant acute myeloid leukemia with MLL gene rearrangement, CANC GENET, 114(1), 1999, pp. 68-70
Citations number
19
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER GENETICS AND CYTOGENETICS
ISSN journal
01654608 → ACNP
Volume
114
Issue
1
Year of publication
1999
Pages
68 - 70
Database
ISI
SICI code
0165-4608(19991001)114:1<68:T(IAIA>2.0.ZU;2-Z
Abstract
Molecular rearrangements of the MLL gene at the 11q23 region have been iden tified in most cases of infant leukemia, regardless of the phenotype. We pr esent a case of acute myeloid leukemia which coexpressed myeloid and lympho id markers in a 12-month-old girl. Karyotype analysis revealed the presence of a thus far unreported translocation t(10;11)(p13;p15). Although no 11q2 3 abnormalities were cytogenetically detectable, an MLL gene molecular rear rangement was found. (C) Elsevier Science Inc., 1999. All rights reserved.