Structural abnormalities of chromosome 2 in Benign thyroid tumors - Three new cases and review of the literature

Here we report our cytogenetic findings on three cases of nodular goiter, a ll showing structural clonal abnormalities of chromosome 2. In the first ca se, we found a t(2;3)(q21;q27 or, q28) in two nodules of the same patient. The second case revealed a t(2;20;3)(p21;q11.2;p25), and the third case sho wed a t(1;2)(p22;p13). When the data from the literature and the present ca ses are summarized, the results suggest the existence of at least three bre akpoint clusters of chromosome 2 in benign thyroid tumors or hyperplasias. (C) Elsevier Science Inc., 1999. All rights reserved.