Platelet aggregation assessment after therapeutic administration of a GP II
b/IIIa inhibitor has been difficult in routine practice due to the inherent
nature of platelet preparation and aggregometry, Platelet microaggregation
was performed via the utilisation of a Coulter counter, Citrate and hepari
n were evaluated as the anticoagulants, and ADP and adrenaline were evaluat
ed as the stimulants, Aprotinin was also assessed. ReoPro was utilised in a
ll assays as the GP IIb/IIIa inhibitor, Platelet microaggregation using the
described methodology provides a quick, simple, reliable, and clinically v
alid method of assessing the percentage platelet inhibition due to the pres
ence of a GP IIb/IIIa inhibitor.