A quick simple method of determining platelet aggregability bellowing glycoprotein IIb/IIIa receptor inhibitor administration

Platelet aggregation assessment after therapeutic administration of a GP II b/IIIa inhibitor has been difficult in routine practice due to the inherent nature of platelet preparation and aggregometry, Platelet microaggregation was performed via the utilisation of a Coulter counter, Citrate and hepari n were evaluated as the anticoagulants, and ADP and adrenaline were evaluat ed as the stimulants, Aprotinin was also assessed. ReoPro was utilised in a ll assays as the GP IIb/IIIa inhibitor, Platelet microaggregation using the described methodology provides a quick, simple, reliable, and clinically v alid method of assessing the percentage platelet inhibition due to the pres ence of a GP IIb/IIIa inhibitor.