Translocation of HSP27 and MKBP in ischemic heart

Authors
Yoshida, K Aki, T Harada, K Shama, KMA Kamoda, Y Suzuki, A Ohno, S
Citation
K. Yoshida et al., Translocation of HSP27 and MKBP in ischemic heart, CELL STRUCT, 24(4), 1999, pp. 181-185
Citations number
23
Categorie Soggetti
Cell & Developmental Biology
Journal title
CELL STRUCTURE AND FUNCTION
ISSN journal
03867196 → ACNP
Volume
24
Issue
4
Year of publication
1999
Pages
181 - 185
Database
ISI
SICI code
0386-7196(199908)24:4<181:TOHAMI>2.0.ZU;2-U
Abstract
HSP27 and MKBP translocate from the cytosolic to myofibril fraction in isch emic rat heart as demonstrated by immunoblotting. Immunohistochemistry anal ysis showed that ischemia enhances the Z line labeling of HSP27 and MKBP. T wo dimensional gel electrophoresis showed that ischemia increases the hyper phosphorylated form of HSP27. These data suggest that HSP27 and MKBP may be involved in the Z line protection against postischemic reperfusion injury.