An unusual matrix of stereocomplementarity in the hydroxylation of monohydroxy fatty acids catalysed by cytochrome P-450 from Bacillus megaterium with potential application in biotransformations

Authors
Ahmed, F Al-Mutairi, EH Avery, KL Cullis, PM Primrose, WU Roberts, GCK Willis, CL
Citation
F. Ahmed et al., An unusual matrix of stereocomplementarity in the hydroxylation of monohydroxy fatty acids catalysed by cytochrome P-450 from Bacillus megaterium with potential application in biotransformations, CHEM COMMUN, (20), 1999, pp. 2049-2050
Citations number
15
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
20
Year of publication
1999
Pages
2049 - 2050
Database
ISI
SICI code
1359-7345(1999):20<2049:AUMOSI>2.0.ZU;2-I
Abstract
Cytochrome P-450 from Bacillus megaterium catalyses the diastereoselective hydroxylations of 13-hydroxymyristic acid, to predominantly erythro-12,13-d ihydroxymyristic acid, and of 12-hydroxymyristic acid to give predominantly threo-12,13-dihydroxymyristic acid, in reactions that are stereocomplement ary and with considerable potential application in biotransformations.