Development in the research of molecular mechanism of Alzheimer's disease

Alzheimer's disease (AD) is a kind of central nervous system disease. The c ause of AD is unclear. It is found that the remarkable histopathological ch aracters of AD are senile plaques and neurofibrillary tangles. beta-amyloid plays an important role in the formation of senile plaques and the abnorma l phosphorylation of Tau protein is the main reason of neurofibrillary tang les. Apolipoprotein E is correlated to AD's access, and the third pathologi cal character-AMY plaque perhaps represents a new cause of AD. Presenlin an d proteinaceous infectious particles are also related with AD. A summary of molecular mechanism for AD and the development of research is presented.